For our families coming from Florida we highly recommend looking into Allegiant Airlines. They are an extremely cost effective way to travel to Knoxville from multiple Florida airports listed below. They do tend to be restrictive in terms of dates, but worth looking into.
(Sanford (SFB), Destin/Fort Walton Beach (VPS), Fort Lauderdale (FLL), Punta Gorda/Fort Myers (PGD), Sarasota (SRQ), St. Pete/Clearwater (PIE), West Palm Beach (PBI).
McGhee Tyson Airport (TYS) is located directly in Knoxville and is approximately a 15 minute drive into Downtown Knoxville. There is also a Hilton hotel that's attached to the Knoxville airport that could be a great option for our families flying in.
Click the link below to visit the airport website.